BAG956
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CAS No. | 853910-02-8 | Cat. No. | BCP01894 |
Name | BAG956 | ||
Synonyms | NVP-BAG956;BAG 956;BAG-956; | ||
SMILES | |||
Chemical Name | |||
Formula | C28H21N5 | M. Wt | 427.5 |
Purity | 98% | Storage | Store at 4-8°C |
Description | BAG 956 is a dual PDK1 and class I PI 3-kinase inhibitor (IC50 values are 245, 56, 446, 35 and 117 nM for PDK1 and PI3K p110 -α, -β, -δ, and -γ respectively). BAG 956 has been shown to inhibit cellular AKT phosphorylation at Thr308. BAG 956 also blocks cell proliferation and causes arrest in the G1 phase of the cell cycle. BAG 956 has been shown to slow tumor progression in mouse xenograft models. |
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