Tpl2 Kinase Inhibitor New
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CAS No. | 871307-18-5 | Cat. No. | BCP16321 |
Name | Tpl2 Kinase Inhibitor | ||
Synonyms | TC-S 7006; TC S 7006; TCS 7006; Tpl2-IN-2p; | ||
SMILES | N#CC1=C(NC2=CC=C(F)C(Cl)=C2)C3=CC(NCC4=CC=CN=C4)=NC=C3N=C1 | ||
Chemical Name | |||
Formula | C21H14ClFN6 | M. Wt | 404.83 |
Purity | 98% | Storage | Store at 4-8°C |
Description | Tpl2 Kinase Inhibitor is a potent and selective Tpl2 (Cot; MAP3K8) inhibitor (IC50 = 50 nM). Selective for Tpl2 over MEK, p38, Src, MK2, PKC and EGFR. Inhibits LPS-induced TNF-α secretion from monocytes and attenuates acute myeloid leukemia (AML) cell proliferation in vitro. Also reduces cytolytic activity of human CD8+ cytotoxic T lymphocytes. Cell permeable. |
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