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Tpl2 Kinase Inhibitor Chemical Structure

Tpl2 Kinase Inhibitor

Data Sheet For research use only. Not for human use.
Cat. No. :BCP16321CAS No. :871307-18-5Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 871307-18-5 Cat. No. BCP16321
Name Tpl2 Kinase Inhibitor
Synonyms TC-S 7006; TC S 7006; TCS 7006; Tpl2-IN-2p;
SMILES N#CC1=C(NC2=CC=C(F)C(Cl)=C2)C3=CC(NCC4=CC=CN=C4)=NC=C3N=C1
Chemical Name
Formula C21H14ClFN6 M. Wt 404.83
Purity 98% Storage Store at 4-8°C
Description Tpl2 Kinase Inhibitor is a potent and selective Tpl2 (Cot; MAP3K8) inhibitor (IC50 = 50 nM). Selective for Tpl2 over MEK, p38, Src, MK2, PKC and EGFR. Inhibits LPS-induced TNF-α secretion from monocytes and attenuates acute myeloid leukemia (AML) cell proliferation in vitro. Also reduces cytolytic activity of human CD8+ cytotoxic T lymphocytes. Cell permeable.
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