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AT9283 Chemical Structure

AT9283

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP11714CAS No. ：896466-04-9Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 896466-04-9 Cat. No. BCP11714
Name AT9283
Synonyms AT 9283; AT-9283; AT-9283 free base;
SMILES O=C(NC1CC1)NC2=CNN=C2C3=NC4=CC=C(C=C4N3)CN5CCOCC5
Chemical Name
Formula C19H23N7O2 M. Wt 381.44
Purity 98% Storage Store at 4-8°C
Description AT9283 is a multikinase inhibitor, is also a small-molecule inhibitor of several kinases with potential antineoplastic activity. Multikinase inhibitor AT9283 binds to and inhibits Aurora kinases A and B, JAK2 (Janus kinase 2) and the kinase BCR-ABL, which may result in the inhibition of cellular division and proliferation and the induction of apoptosis in tumor cells that overexpress these kinases. Aurora kinases are serine-threonine kinases that play essential roles in mitotic checkpoint control during mitosis; JAK2 is a kinase that transduces signals from the single chain and IL-3 cytokine receptor families, and from the IFN-gamma receptors; BCR-ABL is a fusion protein with tyrosine kinase activity that is commonly found in CML.
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