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GDC-0941 Chemical Structure

GDC-0941

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP01714CAS No. ：957054-30-7Purity：99%
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  • Publications Citing of Biochempartner's GDC-0941
Nat Med. 2013 Nov; 19(11): 1518–1523. Oncotarget. 2016 Oct 11; 7(41): 67071–67086.
Oncotarget. 2016 May 3; 7(18): 25224–25240.
  • Chemical Properties&Biological Activity
CAS No. 957054-30-7 Cat. No. BCP01714
Name GDC-0941
Synonyms GDC 0941;GDC0941; RG7321; RG-7321; RG 7321; GNE0941; GNE-0941; GNE 0941; Pictrelisib; Pictilisib;
SMILES CS(=O)(=O)N1CCN(CC1)CC2=CC3=C(S2)C(=NC(=N3)C4=C5C=NNC5=CC=C4)N6CCOCC6
Chemical Name
Formula C23H27N7O3S2 M. Wt 513.64
Purity 99% Storage Store at 4-8°C
Description Pictilisib is a small molecule inhibitor of class I phosphatidylinositol 3 kinase (PI3K), with potential antineoplastic activity. Upon administration, pictilisib selectively binds to PI3K in an ATP-competitive manner, inhibiting the production of the secondary messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3) and activation of the PI3K/Akt signaling pathway. This may result in inhibition of tumor cell growth, motility and survival in susceptible tumor cell populations. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis; dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents.
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H-NMR
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