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Y 11 Chemical Structure

Y 11

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP28812CAS No. ：1086639-59-9Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 1086639-59-9 Cat. No. BCP28812
Name Y 11
Synonyms Y11; Y-11;
SMILES O[C@@H]1[C@@H]([C@](O[C@]1NC(N(CC(O)=O)C)=N)CO)O
Chemical Name
Formula C8H17BrN4O M. Wt 265.15
Purity 98% Storage Store at 4-8°C
Description Y11 is a small molecule inhibitor targeting Y397 site of FAK. Y11 significantly and specifically decreased FAK autophosphorylation, directly bound to the N-terminal domain of FAK. In addition, Y11 decreased Y397-FAK autophosphorylation, inhibited viability and clonogenicity of colon SW620 and breast BT474 cancer cells and increased detachment and apoptosis in vitro. Moreover, Y11 significantly decreased tumor growth in the colon cancer cell mouse xenograft model. Finally, tumors from the Y11-treated mice demonstrated decreased Y397-FAK autophosphorylation and activation of poly (ADP ribose) polymerase and caspase-3.
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