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Defactinib Chemical Structure

Defactinib

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP11299CAS No. ：1073154-85-4Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 1073154-85-4 Cat. No. BCP11299
Related Products 1345713-71-4（Defactinib） 1073160-26-5（Defactinib hydrochloride）
Name Defactinib
Synonyms VS-6063;VS6063;VS 6063;PF04554878; PF-04554878; PF 04554878; PF4554878; PF-4554878; PF4554878;
SMILES
Chemical Name
Formula C20H21F3N8O3S M. Wt 510.14
Purity 98% Storage Store at 4-8°C
Description Defactinib, also known as VS-6063 and PF-04554878, is an orally bioavailable, small-molecule focal adhesion kinase (FAK) inhibitor with potential antiangiogenic and antineoplastic activities. FAK inhibitor PF-04554878 inhibits FAK, which may prevent the integrin-mediated activation of several downstream signal transduction pathways, including ERK, JNK/MAPK and PI3K/Akt, thus inhibiting tumor cell migration, proliferation and survival.
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