Desloratadine
Data Sheet
For research use only. Not for human use.
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| CAS No. | 100643-71-8 | Cat. No. | BCP02340 |
| Name | Desloratadine | ||
| Synonyms | SCH-34117;SCH 34117;SCH34117; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C19H19ClN2 | M. Wt | 310.82 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Desloratadine is a competitive antagonist of carbachol-induced contractions in isolated rabbit iris smooth muscle with pA2 of 6.67.Desloratadine binds to the human H1 receptor with Ki value of 0.87 nM in displacing tritiated mepyramine. Desloratadine (100 nM to 10 μM) inhibits both IgE-mediated and non–IgE-mediated generation of the cytokines IL-4 and IL-13 by human basophils. Desloratadine (300 nM to 100 μM) inhibits both IgE and non–IgE-mediated histamine release from human peripheral blood basophils. Desloratadine (0.1 μM to 10 μM) is also shown to inhibit platelet-activating factor-induced eosinophil chemotaxis and TNF-α-induced eosinophil adhesion in eosinophils obtained from patients with allergic rhinitis or allergic asthma. Desloratadine (1 μM-10 μM) dose-dependently inhibits the release of histamine and LTC4 from human basophils. Desloratadine (0.1 μM-10 μM) dose-dependently inhibits IL-13 secretion from basophils activated with IL-3 and PMA from human basophils. Desloratadine | ||
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