U-73122

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP12870CAS No. ：112648-68-7Purity：98%

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CAS No.	112648-68-7	Cat. No.	BCP12870
Name	U-73122
Synonyms	U73122;U 73122;
SMILES
Chemical Name
Formula	C29H40N2O3	M. Wt	464.64
Purity	98%	Storage	Store at 4-8°C
Description	In neutrophils and human platelets, U-73122 inhibits agonist-induced phospholipase C (IC50=1.0-2.1 μM) activation. This compound affects the phospholipases by inhibiting the hydrolysis of PPI (phosphatidylinositol) to IP3 (inositol triphosphate), which in turn leads to a drop in cytosolic Ca2+. In SK-N-SH neuroblastoma cells, U-73122 inhibits agonist-induced down-regulation of muscarinic receptors. In addition, it is a useful tool to investigate receptor-mediated PI turnover in signal transduction. U-73122 is a potent inhibitor of human neutrophil adhesion to biological surfaces (IC50 = 50 nM) as well as adhesion-dependent granule exocytosis and oxidative burst. U-73122 is useful as a negative control for investigations of U-73122 phospholipase C antagonism and its cellular consequences.