SCH 79797 dihydrochloride New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1216720-69-2 | Cat. No. | BCP46793 |
| Related Products | 245520-69-8（SCH 79797） | ||
| Name | SCH 79797 dihydrochloride | ||
| Synonyms | SCH 79797 2HCl;SCH79797 2HCl; | ||
| SMILES | CC(C)C1=CC=C(C=C1)CN2C=CC3=C2C=CC4=C3C(=NC(=N4)NC5CC5)N.Cl.Cl | ||
| Chemical Name | |||
| Formula | C23H27Cl2N5 | M. Wt | 444.41 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | SCH79797 dihydrochloride is a highly potent, selective nonpeptide protease activated receptor 1 (PAR1) antagonist. SCH79797 dihydrochloride inhibits binding of a high-affinity thrombin receptor-activating peptide to PAR1 with an IC50 of 70 nM and a Ki of 35 nM. SCH79797 dihydrochloride inhibits thrombin-induced platelet aggregation with an IC50 of 3 μM. SCH79797 dihydrochloride has antiproliferative and pro-apoptotic effects, and limits myocardial ischemia/reperfusion injury in rat hearts. SCH79797 dihydrochloride also potently prevents PAR1 activation in vascular smooth muscle cells, endothelial cells, and astrocytes. | ||
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