Vonoprazan fumarate New
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| CAS No. | 1260141-27-2 | Cat. No. | BCP05635 |
| Related Products | 881681-00-1（Vonoprazan） 881681-01-2（Vonoprazan Fumarate） | ||
| Name | Vonoprazan fumarate | ||
| Synonyms | TAK-438 fumarate;TAK438 fumarate;TAK 438 fumarate; | ||
| SMILES | CNCC1=CN(C(=C1)C2=CC=CC=C2F)S(=O)(=O)C3=CN=CC=C3.C(=C/C(=O)O)\C(=O)O | ||
| Chemical Name | |||
| Formula | C17H16FN3O2S.C4H4O4 | M. Wt | 461.46 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | TAK-438 is a pyrrole derivative with a chemical structure that is completely different from the P-CABs developed to date. TAK-438 inhibits gastric H+, K+-ATPase activity in a concentration-dependent manner. Under neutral conditions (pH 7.5), the inhibitory activity of TAK-438 is almost the same as that under weakly acidic conditions (pH 6.5). TAK-438 does not inhibit Na+, K+-ATPase activity even at concentration 500 times higher than their IC50 values against gastric H+,K+-ATPase activity. TAK-438 inhibits gastric H+, K+-ATPase in a K+-competitive manner with Ki of 3 nM. | ||
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