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VXc-​486 Chemical Structure

VXc-​486

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP20714CAS No. ：1384984-18-2Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 1384984-18-2 Cat. No. BCP20714
Name VXc-​486
Synonyms VXc486 ;VXc ​486;
SMILES
Chemical Name
Formula C21H25FN6O3 M. Wt 428.46
Purity 98% Storage Store at 4-8°C
Description VXc-486, which targets gyrase B, potently inhibits multiple drug-sensitive isolates and drug-resistant isolates of Mycobacterium tuberculosis in vitro (MICs of 0.03 to 0.30 ug/ml and 0.08 to 5.48 u g/ml, respectively) and reduces mycobacterial burdens in lungs of infected mice in vivo.VXc-486 is active against drug-resistant isolates, has bactericidal activity, and kills intracellular and dormant M. tuberculosis bacteria in a low-oxygen environment. Furthermore, VXc-486 inhibits the growth of multiple strains of M.abscessus, M. avium complex, and M. kansasii (MICs of 0.1 to 2.0 u g/ml), as well as that of several strains of Nocardia spp. (MICs of 0.1 to 1.0 u g/ml).
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