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Berubicin Chemical Structure

Berubicin

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP41505CAS No. ：677017-23-1Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 677017-23-1 Cat. No. BCP41505
Name Berubicin
Synonyms RTA-744; RTA 744; RTA774; WP 769; WP769; WP-769;
SMILES CC1C(C(CC(O1)OC2CC(CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)(C(=O)CO)O)N)OCC6=CC=CC=C6
Chemical Name
Formula C34H35NO11 M. Wt 633.64
Purity 98% Storage Store at 4-8°C
Description Berubicin is a 4'-O-benzylated analogue of the anthracycline derivative doxorubicin, with potential antineoplastic activity. Berubicin intercalates into DNA and interrupts topoisomerase II activity, resulting in the inhibition of DNA replication and repair, as well as RNA and protein synthesis. Unlike other anthracycline derivatives, this agent crosses the blood-brain barrier (BBB) and can circumvent P glycoprotein/MRP1-mediated efflux.
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