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CAS No. | 185425-25-6 | Cat. No. | BCP40436 |
Name | Chimmitecan | ||
Synonyms | (S)-9-Allyl-10-hydroxycamptothecin;9-Allyl-10-Hydroxycamptothecin; | ||
SMILES | CCC1(C2=C(COC1=O)C(=O)N3CC4=CC5=C(C=CC(=C5CC=C)O)N=C4C3=C2)O | ||
Chemical Name | |||
Formula | C23H20N2O5 | M. Wt | 404.42 |
Purity | 98% | Storage | Store at 4-8°C |
Description | Chimmitecan is a potent topoisomerase I inhibitor. Chimmitecan is also an active metabolite of simmitecan. Chimmitecan displays outstanding activity in vitro and in vivo. The substitution at the 9-position benefits chimmitecan a salient anti-MDR activity, stability in human serum albumin, improved solubility, and oral availability, which might favorably promise its therapeutic potential in clinical settings. |
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