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UNC2025 Chemical Structure

UNC2025

Data Sheet For research use only. Not for human use.
Cat. No. :BCP16544CAS No. :1429881-91-3Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 1429881-91-3 Cat. No. BCP16544
Name UNC2025
Synonyms UNC-2025;UNC 2025;
SMILES
Chemical Name
Formula C28H40N6O M. Wt 476.66
Purity 98% Storage Store at 4-8°C
Description UNC2025 was capable of inhibiting Mer phosphorylation in vivo, following oral dosing as demonstrated by pharmaco-dynamic (PD) studies examining phospho-Mer in leukemic blasts from mouse bone marrow. Kinome pro ling versus more than 300 kinases in vitro and cellular selectivity assessments demonstrate that 11 has similar subnanomolar activity against Flt3, an additional important target in acute myelogenous leukemia (AML), with pharmacologically useful selectivity versus other kinases examined.
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