HDM201

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP20814CAS No. ：1448867-41-1Purity：98%

Get Quotation Now

Tel: 0086-17754423994 or orders@biochempartner.com

* Required Fields.

Please complete the form below and you will get the price list in 1 minute.

* Required Fields.

Please complete the form below and we will contact you shortly.

* Required Fields.

Please complete the form below and we will contact you shortly.

CAS No.	1448867-41-1	Cat. No.	BCP20814
Name	HDM201
Synonyms	Siremadlin; HDM 201; HDM-201; NVP-HDM201; NVP-HDM-201; NVP-HDM 201;
SMILES
Chemical Name
Formula	C26H24Cl2N6O4	M. Wt	555.42
Purity	98%	Storage	Store at 4-8°C
Description	HDM201 is an orally bioavailable human double minute 2 homolog (HDM2) inhibitor with potential antineoplastic activity. HDM2 inhibitor HDM201 inhibits the binding of the HDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53. By preventing this HDM2-p53 interaction, the proteosome-mediated enzymatic degradation of p53 is inhibited, which may result in the restoration of both p53 signaling and p53-mediated induction of tumor cell apoptosis. HDM2, a zinc finger protein and negative regulator of the p53 pathway, is often overexpressed in cancer cells and has been implicated in cancer cell proliferation and survival. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).