PK11007 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 38275-34-2 | Cat. No. | BCP30143 |
| Name | PK11007 | ||
| Synonyms | PK-11007; PK 11007; | ||
| SMILES | CS(=O)(=O)C1=NC=C(C(=N1)C(=O)O)Cl | ||
| Chemical Name | |||
| Formula | C6H5ClN2O4S | M. Wt | 236.62 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | PK11007 is an anti-p53 drug. PK11007 stabilizes wild type and mutant p53 through selective alkylation of two surface cysteines without interfering with its DNA binding. PK11007 preferentially decreases viability in p53-compromised cancer cell lines. IC50 values for inhibition of proliferation in a panel of 17 breast cell lines by PK11007 ranged from 2.3 to 42.2 μM. | ||
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