CBL0137 New
Data Sheet
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| CAS No. | 1197996-80-7 | Cat. No. | BCP29977 |
| Name | CBL0137 | ||
| Synonyms | CBL-0137; CBL 0137; Curaxin 137; | ||
| SMILES | CC(C)NCCN1C2=C(C=C(C=C2)C(=O)C)C3=C1C=CC(=C3)C(=O)C | ||
| Chemical Name | |||
| Formula | C21H24N2O2 | M. Wt | 336.43 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | CBL0137, also known as Curaxin 137, is a metabolically stable curaxin that activates p53 with an EC50 value of 0.37 µM and inhibits NF-κB with an EC50 of 0.47 µM. CBL0137 inhibits histone chaperone FACT, is efficacious in preclinical orthotopic models of temozolomide-responsive and -resistant glioblastoma. CBL0137 eradicates drug resistant cancer stem cells and potentiates efficacy of gemcitabine in preclinical models of pancreatic cancer. | ||
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