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Tetomilast Chemical Structure

Tetomilast

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP45927CAS No. ：145739-56-6Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 145739-56-6 Cat. No. BCP45927
Name Tetomilast
Synonyms OPC6535; OPC-6535; OPC 6535;
SMILES CCOC1=C(C=C(C=C1)C2=NC(=CS2)C3=NC(=CC=C3)C(=O)O)OCC
Chemical Name
Formula C19H18N2O4S M. Wt 370.42
Purity 98% Storage Store at 4-8°C
Description Tetomilast, also known as OPC6535, is a novel thiazole phosphodiesterase-4 (PDE-4) inhibitor, which may prove useful in both the treatment of inflammatory bowel disease (IBD) and chronic obstructive pulmonary disease (COPD). Tetomilast attenuates elastase-induced pulmonary emphysema through inhibition of oxidative stress in rabbits. Tetomilast suppressed production of proinflammatory cytokines from human monocytes and ameliorated chronic colitis in IL-10-deficient mice.
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