JJKK048 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1515855-97-6 | Cat. No. | BCP46517 |
| Name | JJKK048 | ||
| Synonyms | JJKK-048; JJKK 048; | ||
| SMILES | C1CN(CCC1C(C2=CC3=C(C=C2)OCO3)C4=CC5=C(C=C4)OCO5)C(=O)N6C=NC=N6 | ||
| Chemical Name | |||
| Formula | C23H22N4O5 | M. Wt | 434.44 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | JJKK048 is an ultrapotent and highly selective inhibitors of monoacylglycerol lipase. JJKK-048 potently (IC50 < 0.4 nM) inhibited human and rodent MAGL. JJKK-048 displayed low cross-reactivity with other endocannabinoid targets. Monoacylglycerol lipase (MAGL) terminates the signaling function of the endocannabinoid, 2-arachidonoylglycerol (2-AG). During 2-AG hydrolysis, MAGL liberates arachidonic acid, feeding the principal substrate for the neuroinflammatory prostaglandins. In cancer cells, MAGL redirects lipid stores toward protumorigenic signaling lipids. Thus MAGL inhibitors may have great therapeutic potential. | ||
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