JZP-430 New
Data Sheet
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| CAS No. | 1672691-74-5 | Cat. No. | BCP39983 |
| Name | JZP-430 | ||
| Synonyms | JZP 430; JZP430; | ||
| SMILES | CN(C1CCCCCCC1)C(=O)OC2=NSN=C2N3CCOCC3 | ||
| Chemical Name | |||
| Formula | C16H26N4O3S | M. Wt | 354.47 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | JZP-430 is a potent and selective ABHD6 inhibitor. P-430 potently and irreversibly inhibited hABHD6 (IC50 =44 nM) and showed ∼230-fold selectivity over fatty acid amide hydrolase (FAAH) and lysosomal acid lipase (LAL), the main off-targets of related compounds. Additionally, activity-based protein profiling indicated that JZP-430 displays good selectivity among the serine hydrolases of the mouse brain membrane proteome. JZP-430 has been identified as a highly selective, irreversible inhibitor of hABHD6, which may provide a novel approach in the treatment of obesity and type II diabetes. | ||
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