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Cycloguanil hydrochloride Chemical Structure

Cycloguanil hydrochloride

Data Sheet For research use only. Not for human use.
Cat. No. :BCP34872CAS No. :152-53-4Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 152-53-4 Cat. No. BCP34872
Name Cycloguanil hydrochloride
Synonyms Cycloguanil HCl;AI3-26080; BN 2410; NSC 3074;
SMILES CC1(N=C(N=C(N1C2=CC=C(C=C2)Cl)N)N)C.Cl
Chemical Name
Formula C11H15Cl2N5 M. Wt 288.18
Purity 98% Storage Store at 4-8°C
Description Cycloguanil hydrochloride is the hydrochloride salt of cycloguanil. Cycloguanil is a dihydrofolate reductase inhibitor, and is a metabolite of the antimalarial drug proguanil; its formation in vivo has been thought to be primarily responsible for the antimalarial activity of proguanil. However, more recent work has indicated that, while proguanil is synergistic with the drug atovaquone (as in the combination Malarone), cycloguanil is in fact antagonistic to the effects of atovaquone, suggesting that, unlike cycloguanil, proguanil may have an alternative mechanism of antimalarial action besides dihydrofolate reductase inhibition.
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