Rupatadine New

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP02444CAS No. ：158876-82-5Purity：98%

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CAS No.	158876-82-5	Cat. No.	BCP02444
Related Products	182349-12-8（Rupatadine fumarate）
Name	Rupatadine
Synonyms	UR-12592;UR 12592;UR12592;Rupafi;
SMILES	CC1=CN=CC(CN2CC/C(CC2)=C3C4=CC=C(Cl)C=C4CCC5=CC=CN=C5\3)=C1
Chemical Name
Formula	C26H26ClN3	M. Wt	415.96
Purity	98%	Storage	Store at 4-8°C
Description	Rupatadine inhibits both platelet-activating factor (PAF) and histamine (H1) effects through its interaction with specific receptors. Rupatadine competitively inhibits histamine-induced guinea pig ileum contraction (pA2 = 9.29 ± 0.06) without affecting contraction induced by ACh, serotonin or leukotriene D4(LTD4). It also competitively inhibits PAF-induced platelet aggregation in washed rabbit platelets (WRP) (pA2= 6.68 ± 0.08) and in human platelet-rich plasma (HPRP) (IC50 = 0.68 μM), while not affecting ADP- or arachidonic acid-induced platelet aggregation.In another study, it is reported rupatadine and loratadine shows similar inhibitory effect on histamine and TNF-α release, whereas SR-27417A only exhibits inhibitory effect against TNF-α.