Rupatadine fumarate
Data Sheet
For research use only. Not for human use.
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| CAS No. | 182349-12-8 | Cat. No. | BCP05230 |
| Related Products | 158876-82-5（Rupatadine） | ||
| Name | Rupatadine fumarate | ||
| Synonyms | UR-12592 Fumarate;UR12592 Fumarate;UR 12592 Fumarate; Rupafin; Alergoliber; Rinialer; Pafinur; Rupax; Ralif; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C26H26ClN3.C4H4O4 | M. Wt | 532.03 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Rupatadine inhibits both platelet-activating factor (PAF) and histamine (H1) effects through its interaction with specific receptors. Rupatadine competitively inhibits histamine-induced guinea pig ileum contraction (pA2 = 9.29 ± 0.06) without affecting contraction induced by ACh, serotonin or leukotriene D4(LTD4). It also competitively inhibits PAF-induced platelet aggregation in washed rabbit platelets (WRP) (pA2= 6.68 ± 0.08) and in human platelet-rich plasma (HPRP) (IC50 = 0.68 μM), while not affecting ADP- or arachidonic acid-induced platelet aggregation. [1] In another study, it is reported rupatadine and loratadine shows similar inhibitory effect on histamine and TNF-α release, whereas SR-27417A only exhibits inhibitory effect against TNF-α. | ||
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