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CAS No. | 1672662-14-4 | Cat. No. | BCP25901 |
Name | PT2399 | ||
Synonyms | PT-2399; PT 2399; | ||
SMILES | C1C2=C(C=CC(=C2C(C1(F)F)O)S(=O)(=O)C(F)F)OC3=CC(=CC(=C3)C#N)F | ||
Chemical Name | |||
Formula | C17H10F5NO4S | M. Wt | 419.32 |
Purity | 98% | Storage | Store at 4-8°C |
Description | PT2399 is a first-in-class, orally available, small molecule inhibitor of HIF-2 that selectively disrupts the heterodimerization of HIF-2α with HIF-1β. Preclinical and clinical data indicate that PT2399 is effective in blocking cancer cell growth, proliferation, and tumor angiogenesis characteristic in ccRCC. |
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