CM-272 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1846570-31-7 | Cat. No. | BCP32745 |
| Name | CM-272 | ||
| Synonyms | CM 272; CM272; | ||
| SMILES | CC1=CC=C(O1)C2=NC3=CC(=C(C=C3C(=C2)NC4CCN(CC4)C)OC)OCCCN5CCCC5 | ||
| Chemical Name | |||
| Formula | C28H38N4O3 | M. Wt | 478.64 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | CM-272 is a first-in-class, potent, selective, substrate-competitive and reversible dual G9a/DNA methyltransferases (DNMTs) inhibitor. CM-272 inhibits G9a, DNMT1, DNMT3A, DNMT3B and GLP with IC50s of 8 nM, 382 nM, 85 nM, 1200 nM and 2 nM, respectively. CM-272 inhibits cell proliferation and promotes apoptosis, inducing interferon-stimulated genes and immunogenic cell death. Anti-tumour Activity. | ||
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