TBK1/IKKε-IN-5 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1893397-65-3 | Cat. No. | BCP43331 |
| Name | TBK1/IKKε-IN-5 | ||
| Synonyms | TBK1/IKKepsilon-IN-5; | ||
| SMILES | C1COCCC1OC2=C(C=C(C=C2)C3=NC(=NC=N3)NC4=CC=C(C=C4)N5CCN(CC5)C6COC6)C#N | ||
| Chemical Name | |||
| Formula | C28H31N7O3 | M. Wt | 513.59 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | TBK1/IKKε-IN-1 (compound 1) is a dual inhibitor of TANK-binding kinase 1 (TBK1) and IκB kinase-ε (IKKε/IKK-i) with IC50 of 1.0 nM and 5.6 nM for TBK1 and IKKε, respectively. TBK1/IKKε inhibition enhances response to PD-1 blockade, which effectively predicts tumor response in vivo. | ||
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