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CAS No. | 1962178-27-3 | Cat. No. | BCP44964 |
Name | PF-04802367 | ||
Synonyms | PF04802367;PF 04802367;PF367;PF 367;PF-367; | ||
SMILES | COC1=C(C=C(C=C1)C2=C(N=CO2)C(=O)NCCCN3C=NC=N3)Cl | ||
Chemical Name | |||
Formula | C16H16ClN5O3 | M. Wt | 361.78 |
Purity | 98% | Storage | Store at 4-8°C |
Description | PF-04802367 is a highly selective GSK-3 inhibitor with an IC50 of 2.1 nM based on a recombinant human GSK-3β enzyme assay and 1.1 nM based on ADP-Glo assay. PF-04802367 shows desirable central nervous system (CNS) properties and potency. PF-04802367 is equally effective at inhibition of the two known GSK-3 isoforms (GSK-3α and GSK-3β) with IC50 values of 10.0 and 9.0 nM in mobility shift assays, respectively[1]. |
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