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MeriMepodib Chemical Structure

MeriMepodib

Data Sheet For research use only. Not for human use.
Cat. No. :BCP28336CAS No. :198821-22-6Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 198821-22-6 Cat. No. BCP28336
Name MeriMepodib
Synonyms VX497; VX-497; VX 497; MMP; VI21497; VI-21497; VI 21497;
SMILES
Chemical Name
Formula C23H24N4O6 M. Wt 452.46
Purity 98% Storage Store at 4-8°C
Description Merimepodib, also known as VX-497, is orally bioavailable IMPDH inhibitor, which inhibits the proliferation of primary human, mouse, rat, and dog lymphocytes at concentrations of approximately 100 nM. In vivo, oral administration of VX-497 inhibits the primary IgM antibody response in a dose-dependent manner, with an ED(50) value of approximately 30-35 mg/kg in mice. Single daily dosing of VX-497 is observed to be as effective as twice-daily dosing in this model of immune activation. These studies demonstrate that VX-497 is a potent, specific, and reversible IMPDH inhibitor that selectively inhibits lymphocyte proliferation.
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