ATM Inhibitor-5 New
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| CAS No. | 2020089-41-0 | Cat. No. | BCP47340 |
| Name | ATM Inhibitor-5 | ||
| Synonyms | M4076;M 4076;M-4076; | ||
| SMILES | CC1=NN(C=C1C2=C(C=C3C(=C2)C4=C(C=N3)N(C(=O)N4C5=C(C=NC=C5OC)F)C)OC)C | ||
| Chemical Name | |||
| Formula | C23H21FN6O3 | M. Wt | 448.45 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | ATM Kinase Inhibitor M4076 is an orally bioavailable ATP-competitive inhibitor of ataxia telangiectasia mutated kinase (ATM), with potential chemo-/radio-sensitizing and antineoplastic activities. Upon oral administration, M4076 targets and binds to ATM, thereby inhibiting the kinase activity of ATM and ATM-mediated signaling. This prevents DNA damage checkpoint activation, disrupts DNA damage repair, induces tumor cell apoptosis, and leads to cell death of ATM-overexpressing tumor cells. In addition, by preventing DNA damage repair, M4076 sensitizes tumor cells to chemo- and radiotherapy and increases their anti-tumor activity. ATM, a serine/threonine protein kinase upregulated in a variety of cancer cell types, is activated in response to DNA damage and plays a key role in DNA-strand repair. | ||
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