Entecavir hydrate
Data Sheet
For research use only. Not for human use.
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| CAS No. | 209216-23-9 | Cat. No. | BCP01930 |
| Name | Entecavir hydrate | ||
| Synonyms | Entecavir monohydrate; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C12H15N5O3.H2O | M. Wt | 295.29 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Entecavir monohydrate is an oral antiviral drug used in the treatment of hepatitis B infection. Entecavir monohydrate is a nucleoside analog (more specifically, a guanine analogue) that inhibits reverse transcription, DNA replication and transcription in the viral replication process. Entecavir monohydrate is more efficacious than previous agents used to treat hepatitis B (lamivudine and adefovir). Entecavir monohydrate is also indicated for the treatment of chronic hepatitis B in adults with HIV/AIDS infection. However, Entecavir is not active against HIV. Entecavir cumulative urinary excretion was statistically significant at 45 and 60min. CLR(4°C), CLR(37°C Control) and CLR(37°C Experiment) were 12.6, 27.6 and 36 (ml/min/kg), respectively. CLTS and TR rate (for PEPT2) were 25.3 and 9.4 (ml/min/kg). In vivo, the cumulative urinary excretion of entecavir had statistical significance at 3 and 4h with CLR(Control) and CLR(Experiment) values of 31 and 42 (ml/min/kg), respectively. The CL | ||
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