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eIF4A3-IN-1 Chemical Structure

eIF4A3-IN-1

Data Sheet For research use only. Not for human use.
Cat. No. :BCP45171CAS No. :2095486-67-0Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 2095486-67-0 Cat. No. BCP45171
Name eIF4A3-IN-1
Synonyms
SMILES CC1=C(C=NN1C2=CC=CC(=C2)C#N)C(=O)N3CCN(C(C3)C4=CC=C(C=C4)Cl)C(=O)C5=CC=C(C=C5)Br
Chemical Name
Formula C29H23BrClN5O2 M. Wt 588.88
Purity 98% Storage Store at 4-8°C
Description eIF4A3-IN-1 is a selective eukaryotic initiation factor 4A3 (eIF4A3) inhibitor (IC50=0.26 μM; Kd=0.043 μM), which binds to a non-ATP binding site of eIF4A3 and shows significant cellular nonsense-mediated RNA decay (NMD) inhibition at 10 and 3 μM and can be as a probe for further study of eIF4A3, the exon junction complex (EJC), and NMD.
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