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Zotatifin Chemical Structure

Zotatifin

Data Sheet For research use only. Not for human use.
Cat. No. :BCP35487CAS No. :2098191-53-6Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 2098191-53-6 Cat. No. BCP35487
Name Zotatifin
Synonyms eFT226; eFT 226; eFT-226;
SMILES CN(C)CC1C(C2(C(C1O)(C3=C(N=C(C=C3O2)OC)OC)O)C4=CC=C(C=C4)C#N)C5=CC=CC=C5
Chemical Name
Formula C28H29N3O5 M. Wt 487.56
Purity 98% Storage Store at 4-8°C
Description Zotatifin (eFT226) is a potent and selective inhibitor of eIF4A, is efficacious in preclinical models of lymphoma. eFT226 promotes eIF4A1 binding to specific 5’-UTR polypurine and/or G-quadraplex recognition motifs leading to a selective block in ribosome mRNA scanning. eFT226 shows potent anti-proliferative activity (GI50 < 15 nM) against a panel of B-cell lymphoma cell lines. Treatment with eFT226 leads to coordinated inhibition of MYC, CCND1/3, BCL2 or MCL1 protein expression resulting in significant anti-tumor activity.
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