Zotatifin New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 2098191-53-6 | Cat. No. | BCP35487 |
| Name | Zotatifin | ||
| Synonyms | eFT226; eFT 226; eFT-226; | ||
| SMILES | CN(C)CC1C(C2(C(C1O)(C3=C(N=C(C=C3O2)OC)OC)O)C4=CC=C(C=C4)C#N)C5=CC=CC=C5 | ||
| Chemical Name | |||
| Formula | C28H29N3O5 | M. Wt | 487.56 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Zotatifin (eFT226) is a potent and selective inhibitor of eIF4A, is efficacious in preclinical models of lymphoma. eFT226 promotes eIF4A1 binding to specific 5’-UTR polypurine and/or G-quadraplex recognition motifs leading to a selective block in ribosome mRNA scanning. eFT226 shows potent anti-proliferative activity (GI50 < 15 nM) against a panel of B-cell lymphoma cell lines. Treatment with eFT226 leads to coordinated inhibition of MYC, CCND1/3, BCL2 or MCL1 protein expression resulting in significant anti-tumor activity. | ||
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