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SBI-0640756 Chemical Structure

SBI-0640756

Data Sheet For research use only. Not for human use.
Cat. No. :BCP23633CAS No. :SBI-0640756Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. SBI-0640756 Cat. No. BCP23633
Name SBI-0640756
Synonyms SBI 0640756;SBI0640756;SBI 756;SBI756;SBI-756;
SMILES O=C1C(C(/C=C/C2=CC(F)=CN=C2)=O)=C(C3=CC=CC=C3)C4=C(C=CC(Cl)=C4)N1
Chemical Name
Formula C23H14ClFN2O2 M. Wt 404.82
Purity 98% Storage Store at 4-8°C
Description SBI-0640756(SBI-756) is a first-in-class inhibitor that targets eIF4G1 and disrupts the eIF4F complex. SBI-756 also suppressed AKT and NF-κB signaling. 1) SBI-756 inhibited the growth of NRAS, BRAF, and NF1-mutant melanomas . 2) SBI-756 attenuates resistance to BRAFi and inhibits NRAS- and NF1-mutant melanomas. 3) SBI-756 delayed the onset and reduced the incidence of Nras/Ink4a melanomas
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