SBI-0640756
Data Sheet
For research use only. Not for human use.
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| CAS No. | SBI-0640756 | Cat. No. | BCP23633 |
| Name | SBI-0640756 | ||
| Synonyms | SBI 0640756;SBI0640756;SBI 756;SBI756;SBI-756; | ||
| SMILES | O=C1C(C(/C=C/C2=CC(F)=CN=C2)=O)=C(C3=CC=CC=C3)C4=C(C=CC(Cl)=C4)N1 | ||
| Chemical Name | |||
| Formula | C23H14ClFN2O2 | M. Wt | 404.82 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | SBI-0640756（SBI-756） is a first-in-class inhibitor that targets eIF4G1 and disrupts the eIF4F complex. SBI-756 also suppressed AKT and NF-κB signaling. 1) SBI-756 inhibited the growth of NRAS, BRAF, and NF1-mutant melanomas . 2) SBI-756 attenuates resistance to BRAFi and inhibits NRAS- and NF1-mutant melanomas. 3) SBI-756 delayed the onset and reduced the incidence of Nras/Ink4a melanomas | ||
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