Briciclib
Data Sheet
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| CAS No. | 865783-99-9 | Cat. No. | BCP17292 |
| Name | Briciclib | ||
| Synonyms | ON013105; ON-013105; ON 013105;ON-014185;ON 014185;ON014185; | ||
| SMILES | O=S(CC1=CC(OP(O)(O)=O)=C(OC)C=C1)(/C=C/C2=C(OC)C=C(OC)C=C2OC)=O | ||
| Chemical Name | |||
| Formula | C19H23O10PS | M. Wt | 474.42 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Briciclib, also known as ON 013105 or ON 014185, is a benzyl styryl sulfone analog, and a disodium phosphate ester prodrug of ON 013100, with potential antineoplastic activity. Upon hydrolysis, cyclin D modulator ON 013105 is converted to ON 013100, which blocks cyclin D mRNA translation and decreases protein expression of cyclin D. This may induce cell cycle arrest and apoptosis in cancer cells overexpressing cyclin D and eventually decrease tumor cell proliferation. This agent may exhibit synergistic antitumor activity in combination with other chemotherapeutic agents. | ||
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