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Briciclib Chemical Structure

Briciclib

Data Sheet For research use only. Not for human use.
Cat. No. :BCP17292CAS No. :865783-99-9Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 865783-99-9 Cat. No. BCP17292
Name Briciclib
Synonyms ON013105; ON-013105; ON 013105;ON-014185;ON 014185;ON014185;
SMILES O=S(CC1=CC(OP(O)(O)=O)=C(OC)C=C1)(/C=C/C2=C(OC)C=C(OC)C=C2OC)=O
Chemical Name
Formula C19H23O10PS M. Wt 474.42
Purity 98% Storage Store at 4-8°C
Description Briciclib, also known as ON 013105 or ON 014185, is a benzyl styryl sulfone analog, and a disodium phosphate ester prodrug of ON 013100, with potential antineoplastic activity. Upon hydrolysis, cyclin D modulator ON 013105 is converted to ON 013100, which blocks cyclin D mRNA translation and decreases protein expression of cyclin D. This may induce cell cycle arrest and apoptosis in cancer cells overexpressing cyclin D and eventually decrease tumor cell proliferation. This agent may exhibit synergistic antitumor activity in combination with other chemotherapeutic agents.
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