CC-92480 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 2259648-80-9 | Cat. No. | BCP32805 |
| Name | CC-92480 | ||
| Synonyms | CC 92480; CC92480; | ||
| SMILES | N#CC1=CC=C(N2CCN(CC3=CC=C(COC4=CC=CC5=C4CN([C@@H](CC6)C(NC6=O)=O)C5=O)C=C3)CC2)C(F)=C1 | ||
| Chemical Name | |||
| Formula | C32H30FN5O4 | M. Wt | 567.62 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | CC-92480 is a cereblon E3 ubiquitin ligase modulating agent with potential immunomodulating and antineoplastic activities. CC-92480 specifically binds to cereblon (CRBN), thereby affecting the ubiquitin E3 ligase activity, and targeting certain substrate proteins for ubiquitination. This induces proteasome-mediated degradation of certain transcription factors, some of which are transcriptional repressors in T cells. This leads to modulation of the immune system, including activation of T lymphocytes, and downregulation of the activity of other proteins, some of which play key roles in the proliferation of certain cancer cell types. | ||
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