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PF03491390 Chemical Structure

PF03491390

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP07463CAS No. ：254750-02-2Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 254750-02-2 Cat. No. BCP07463
Name PF03491390
Synonyms Emricasan;IDN6556;IDN 6556;IDN-6556;PF-03491390;PF 03491390;
SMILES
Chemical Name
Formula C26H27F4N3O7 M. Wt 569.5
Purity 98% Storage Store at 4-8°C
Description Emricasan, also known as IDN 6556 and PF 03491390, is a first-in-class caspase inhibitor in clinical trials for the treatment of liver diseases. Emricasan (IDN-6556) decreases liver injury and fibrosis in a murine model of non-alcoholic steatohepatitis. IDN6556 facilitates marginal mass islet engraftment in a porcine islet autotransplant model. Oral IDN-6556 may lower aminotransferase activity in patients with chronic hepatitis C. Orally-administered PF-03491390 is retained in the liver for prolonged periods with low systemic exposure, exerting a hepatoprotective effect against alpha-fas-induced liver injury in a mouse model.
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