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CAS No. | 2743427-26-9 | Cat. No. | BCP46447 |
Name | GSK215 | ||
Synonyms | GSK-215;GSK 215; | ||
SMILES | |||
Chemical Name | |||
Formula | C50H59F3N10O6S | M. Wt | 985.14 |
Purity | 98% | Storage | Store at 4-8°C |
Description | GSK215 is a potent and selective PROTAC focal adhesion kinase (FAK) degrader. GSK215 is designed by a binder for the VHL E3 ligase and the FAK inhibitor VS-4718. GSK215 induces rapid and prolonged FAK degradation, giving a long-lasting effect on FAK levels and a marked pharmacokinetic/pharmacodynamics (PK/PD) disconnect. |
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