NVP TAE226
Data Sheet
For research use only. Not for human use.
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| CAS No. | 761437-28-9 | Cat. No. | BCP06482 |
| Name | NVP TAE226 | ||
| Synonyms | NVPTAE226;NVP-TAE226;TAE226;TAE226;TAE 226; | ||
| SMILES | O=C(C1=C(C=CC=C1)NC2=NC(NC3=C(C=C(C=C3)N4CCOCC4)OC)=NC=C2Cl)NC | ||
| Chemical Name | |||
| Formula | C23H25ClN6O3 | M. Wt | 468.94 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | NVP-TAE226 is a novel and potent ATP competitive inhibitor of FAK and IGF-IR with potential anticancer activity. TAE226 can block FAK and IGF-IR signaling pathways. TAE226 inhibited the phosphorylation of FAK as well as the downstream effectors AKT, extracellular signal-related kinase, and S6 ribosomal protein in multiple glioma cell lines. TAE226 induced a concentration-dependent decrease in cellular proliferation with an associated G(2) cell cycle arrest in every cell line and an increase in apoptosis in a cell-line-specific manner. TAE226 also decreased glioma cell adhesion, migration, and invasion through an artificial extracellular matrix. | ||
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