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RMC-7977 Chemical Structure

RMC-7977

Data Sheet For research use only. Not for human use.
Cat. No. :BCP49669CAS No. :2765082-12-8Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 2765082-12-8 Cat. No. BCP49669
Name RMC-7977
Synonyms RMC 7977;RMC7977;
SMILES CCN1C2=C3C=C(C=C2)C4=CSC(=N4)CC(C(=O)N5CCCC(N5)C(=O)OCC(CC3=C1C6=C(N=CC(=C6)N7CCN(CC7)C8CC8)C(C)OC)(C)C)NC(=O)C9C1C9COC1
Chemical Name
Formula C47H60N8O6S M. Wt 865.1
Purity 98% Storage Store at 4-8°C
Description RMC-7977 is a reversible, tri-complex RAS inhibitor with broad spectrum activity for both mutant and wild-type (WT) KRAS, NRAS, and HRAS variants.RMC-7977 can lead to tumor regressions and was well tolerated in diverse RAS-addicted preclinical cancer models. RMC-7977 also can inhibit the growth of KRASG12C cancer models.
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