SB408124
Data Sheet
For research use only. Not for human use.
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| CAS No. | 288150-92-5 | Cat. No. | BCP02343 |
| Name | SB408124 | ||
| Synonyms | SB-408124;SB 408124; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C19H18F2N4O | M. Wt | 356.38 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | SB-408124 binds hypocretin type 1 receptor (HcrtR1) with pKi values of 7.57. Calcium mobilization studies shows that SB-408124 is a functional antagonist of the OX1 receptor with a affinity of approximately 50-fold selectivity over the OX2 receptor. A recent study indicates that pretreatment of primary cultures of rat astrocytes with SB-401824 before Orexin A administration significantly reduced the stimulatory action of Orexin A on both basal and forskolin-acivated cAMP production. | ||
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