Tivozanib
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CAS No. | 475108-18-0 | Cat. No. | BCP01980 |
Related Products | 682745-41-1(Tivozanib hydrochloride hydrate) | ||
Name | Tivozanib | ||
Synonyms | AV-951;AV951;AV 951; KRN951; KRN 951; KRN-951; | ||
SMILES | O=C(NC1=NOC(C)=C1)NC2=CC=C(OC3=CC=NC4=CC(OC)=C(OC)C=C34)C=C2Cl | ||
Chemical Name | |||
Formula | C22H19ClN4O5 | M. Wt | 454.86 |
Purity | 98% | Storage | Store at 4-8°C |
Description | Tivozanib, also known as KRN951, is an orally bioavailable inhibitor of vascular endothelial growth factor receptors (VEGFRs) 1, 2 and 3 with potential antiangiogenic and antineoplastic activities. Tivozanib binds to and inhibits VEGFRs 1, 2 and 3, which may result in the inhibition of endothelial cell migration and proliferation, inhibition of tumor angiogenesis and tumor cell death. VEGFR tyrosine kinases, frequently overexpressed by a variety of tumor cell types, play a key role in angiogenesis. |
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