Vorolanib New

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP30430CAS No. ：1013920-15-4Purity：98%

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CAS No.	1013920-15-4	Cat. No.	BCP30430
Name	Vorolanib
Synonyms	CM-082; X-82; CM082; X82; CM 082; X 82;
SMILES	CC1=C(NC(=C1C(=O)NC2CCN(C2)C(=O)N(C)C)C)C=C3C4=C(C=CC(=C4)F)NC3=O
Chemical Name
Formula	C23H26FN5O3	M. Wt	439.48
Purity	98%	Storage	Store at 4-8°C
Description	Vorolanib is an orally available small molecule dual inhibitor targeting human vascular endothelial growth factor receptors (VEGFRs) and platelet-derived growth factor receptors (PDGFRs) with antiangiogenic and antineoplastic activities. Vorolanib inhibits all isoforms of VEGFR and PDGFR, which may result in the inhibition of tumor angiogenesis and tumor cell proliferation, and the induction of tumor cell death. Both VEGFRs and PDGFRs are receptor tyrosine kinases that may be upregulated in various tumor cell types. Vorolanib has been shown to reduce tissue toxicity by 95 percent compared with first-generation kinase inhibitors.