Fluocinolone New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 807-38-5 | Cat. No. | BCP36573 |
| Name | Fluocinolone | ||
| Synonyms | 6-alpha-Fluorotriamcinolone; | ||
| SMILES | CC12CC(C3(C(C1CC(C2(C(=O)CO)O)O)CC(C4=CC(=O)C=CC43C)F)F)O | ||
| Chemical Name | |||
| Formula | C21H26F2O6 | M. Wt | 412.42 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Fluocinolone is a synthetic glucocorticoid with anti-inflammatory and antipruritic activities. Fluocinolone binds the glucocorticoid receptor, followed by translocation of the ligand-receptor complex to the nucleus and transcription activation of genes containing glucocorticoid-responsive elements. Lipocortin-1 is one factor induced by fluocinolone that interacts with and inhibits cytosolic phospholipase 2 alpha, thereby preventing phospholipase translocation to the perinuclear membrane and subsequent release and conversion of arachidonic acid to inflammatory prostaglandins. In addition, MAPK phosphatase 1 is induced, thereby preventing the triggering of the MAPK cascade resulting in pro-inflammatory effects via Jun N-terminal kinase and c-Jun. Finally, fluocinolone binds to and inhibits nuclear factor kappa-B directly, resulting in inhibition of cyclooxygenase 2 transcription and subsequent prostaglandin synthesis. | ||
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