Fluticasone New

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP31287CAS No. ：90566-53-3Purity：98%

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CAS No.	90566-53-3	Cat. No.	BCP31287
Name	Fluticasone
Synonyms	Fluticasonum;
SMILES	CC1CC2C3CC(C4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)SCF)O)C)O)F)C)F
Chemical Name
Formula	C22H27F3O4S	M. Wt	444.51
Purity	98%	Storage	Store at 4-8°C
Description	Fluticasone is a synthetic trifluorinated glucocorticoid receptor agonist with antiallergic, antiinflammatory and antipruritic effects. Fluticasone binds and activates glucocorticoid receptor, resulting in the activation of lipocortin. Lipocortin, in turn, inhibits cytosolic phospholipase A2, which triggers a cascade of reactions involved in the synthesis of inflammatory mediators, such as prostaglandins and leukotrienes. Secondly, mitogen-activated protein kinase (MAPK) phosphatase 1 is induced, thereby leads to dephosphorylation and inactivation of Jun N-terminal kinase directly inhibiting c-Jun mediated transcription. Finally, transcriptional activity of nuclear factor (NF)-kappa-B is blocked, thereby inhibits the transcription of cyclooxygenase 2, which is essential for prostaglandin production.