Delapril hydrochloride New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 83435-67-0 | Cat. No. | BCP14202 |
| Name | Delapril hydrochloride | ||
| Synonyms | Delapril HCl;CV-3317;CV 3317;CV3317; | ||
| SMILES | CCOC(=O)C(CCC1=CC=CC=C1)NC(C)C(=O)N(CC(=O)O)C2CC3=CC=CC=C3C2.Cl | ||
| Chemical Name | |||
| Formula | C26H32N2O5.HCl | M. Wt | 489.01 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Delapril Hydrochloride is the hydrochloride salt of delapril, a lipophilic, non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, delapril is converted to two active metabolites, delapril diacid and 5-hydroxy delapril diacid, which competitively bind to and inhibit ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Delapril also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow. | ||
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