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GSK-189254 hydrochloride Chemical Structure

GSK-189254 hydrochloride

Data Sheet For research use only. Not for human use.
Cat. No. :BCP23443CAS No. :945493-87-8Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 945493-87-8 Cat. No. BCP23443
Name GSK-189254 hydrochloride
Synonyms GSK 189254A; GSK189254A; GSK-189254A; GSK 189254 HCl;
SMILES
Chemical Name
Formula C21H25N3O2.HCl M. Wt 387.91
Purity 98% Storage Store at 4-8°C
Description GSK-189,254 is a potent and selective H3-receptor inverse agonist developed by GlaxoSmithKline. It has subnanomolar affinity for the H3 receptor (Ki 0.2nM) and selectivity of over 10,000x for H3 over other histamine receptor subtypes.Animal studies have shown it to possess not only stimulant and nootropic effects, but also analgesic action suggesting a role for H3 receptors in pain processing in the spinal cord. GSK-189,254 and several other related drugs are currently being investigated as a treatment for Alzheimer's disease and other forms of dementia, as well as possible use in the treatment of conditions such as narcolepsy, or neuropathic pain which do not respond well to conventional analgesic drugs.
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