GDC0575 hydrochloride New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1196504-54-7 | Cat. No. | BCP30767 |
| Name | GDC0575 hydrochloride | ||
| Synonyms | RG7741 HCl;ARRY-575 HCl;RG 7741 HCl;ARRY575 HCl;GDC0575 HCl;GDC 0575 HCl;GDC-0575 HCl;GDC0575 monohydrochloride;GDC 0575 hydrochloride;GDC-0575 hydrochloride; | ||
| SMILES | O=C(C1CC1)NC2=CNC3=NC=C(Br)C(N4C[C@H](N)CCC4)=C32.[H]Cl | ||
| Chemical Name | |||
| Formula | C16H21BrClN5O | M. Wt | 414.73 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | GDC-0575, also known as ARRY-575 and RG7741, is a potent and selective inhibitor of cell cycle checkpoint kinase 1 (Chk1) with an IC50 of 1.2 nM. Chk1 inhibitor GDC-0575 specifically binds to and inhibits Chk1; this may result in tumor cells bypassing Chk1-dependent cell cycle arrest in the S and G2/M phases, which permits the cells to undergo DNA repair prior to entry into mitosis. | ||
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