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Chk2 Inhibitor Chemical Structure

Chk2 Inhibitor

Data Sheet For research use only. Not for human use.
Cat. No. :BCP46034CAS No. :724708-21-8Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 724708-21-8 Cat. No. BCP46034
Name Chk2 Inhibitor
Synonyms Hymenialdisine Analogue 1;CHK2;SC-203885; SC 203885; SC203885;
SMILES C1CNC(=O)C2=NC3=CC=CC=C3C2=C1C4=C(N=C(N4)N)O
Chemical Name
Formula C15H13N5O2 M. Wt 295.3
Purity 98% Storage Store at 4-8°C
Description Chk2 inhibitor is an inhibitor of checkpoint kinase 2 (Chk2; IC50 = 13.5 nM). Chk2 inhibitor enhances survival of 184B5, but not MDA-MB-231, cells following ionizing radiation and inhibits cell cycle arrest at the G2 stage induced by ionizing radiation in 184B5 cells. It also inhibits the production of IL-2 in Jurkat cells, the production of TNF-α in LPS-stimulated THP-1 cells and the growth of CEM leukemia T cells.
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