Prexasertib dimesylate New
Data Sheet
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| CAS No. | 1234015-58-7 | Cat. No. | BCP35489 |
| Related Products | 1234015-55-4（Prexasertib mesylate） 1234015-52-1（Prexasertib） 1234015-54-3（Prexasertib dihydrochloride） 1234015-57-6（Prexasertib Mesylate Hydrate） | ||
| Name | Prexasertib dimesylate | ||
| Synonyms | LY2606368 dimesylate;LY-2606368 dimesylate;LY 2606368 dimesylate; | ||
| SMILES | N#CC1=NC=C(NC2=NNC(C3=C(OC)C=CC=C3OCCCN)=C2)N=C1.CS(=O)(O)=O.CS(=O)(O)=O | ||
| Chemical Name | |||
| Formula | C20H27N7O8S2 | M. Wt | 557.60 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Prexasertib dimesylate (LY2606368 dimesylate) is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a Ki of 0.9 nM and an IC50 of <1 nM. Prexasertib dimesylate inhibits CHK2 (IC50=8 nM) and RSK1 (IC50=9 nM). Prexasertib dimesylate causes double-stranded DNA breakage and replication catastrophe resulting in apoptosis. Prexasertib dimesylate shows potent anti-tumor activity. | ||
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