GDC0575
Data Sheet
For research use only. Not for human use.
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| CAS No. | 2097938-64-0 | Cat. No. | BCP25421 |
| Name | GDC0575 | ||
| Synonyms | GDC-0575; GDC 0575; ARRY-575; ARRY-575; ARRY575; RG7741; RG-7741; RG 7741; AK 687476; AK-687476; AK687476; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C17H21BrN4O | M. Wt | 377.28 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | GDC-0575, also known as ARRY-575 and RG7741, is a potent and selective CHK1 inhibitor. GDC-0575 specifically binds to and inhibits Chk1; this may result in tumor cells bypassing Chk1-dependent cell cycle arrest in the S and G2/M phases, which permits the cells to undergo DNA repair prior to entry into mitosis. Therefore, Chk1 inhibition may sensitize tumor cells to the DNA damaging effects of certain chemotherapeutic agents. Chk1 is an ATP-dependent serine-threonine kinase that phosphorylates cdc25 phosphatases in response to DNA damage. | ||
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